戊 & Butyric Acid: keys to unlocking superior gut health and performance
在动物生产中使用单链脂肪酸(SCFAs)作为添加剂是一种普遍且被广泛接受的做法. The benefits of adding SCFAs to the diet are wide ranging, 包括改善饲料卫生和胃酸化，以更好地控制病原体等等. While their mode of action is not completely understood yet, the scientific community continues to work and update industry knowledge. The most recent discovery is the importance of valeric acid in the gut. When valeric acid is combined with butyric acid, 有机酸组合的协同效应比其各部分的总和提供更多, supporting gut health and unlocking superior levels of flock performance.
Butyric acid and gut health
肠道健康 has a direct impact on animal performance. Although t在这里 is no clear definition for gut health, in most of the cases experts refer to different functions including:
- nutrient digestion and adsorption
- 稳定的微生物
- optimal barrier function (development of the mucus layer and epithelial cell integrity)
- absence of diseases and infections
- effective immune system
- 一般的幸福
- Directly impacting the epithelial function by providing energy to epithelial cells, supporting electrolyte transport, 调节pH值
- 促进粘液的产生，从而支持上皮细胞与外界之间屏障的稳定性
- Impacting the intestinal barrier function by supporting epithelial cell integrity, 减少磁导率, and promoting tight junction expression
- Positively affecting mucosal immune function
- Inducing expression of antimicrobial proteins (defensins and cathelicidins)
- 影响肠神经系统，明显影响上皮细胞的运动
- A positive impact on the immune function of the animals
- Increased epithelial cell function
- A reduction of pathogen counts
- 正如最近关于在家禽生产中使用丁酸的评论所描述的那样，整个胃肠道的总体积极影响
丁酸在家禽生产中的使用是公认的，其对生产性能的影响是众所周知的, but could its effects be improved even more?
戊 acid: a missing piece?
尽管valeric, 异戊酸和2-甲基丁酸也在胃肠道中由微生物群产生, 它们还没有像它们的一些短链脂肪酸和分支脂肪酸同行那样得到很好的研究. 在这些酸中，戊酸越来越受到人们的关注，特别是用于人体医学. Research into the role of valeric acid in gut health and health in general is ongoing, but thanks to in vitro studies, 小鼠研究, 根据流行病学观察我们知道，例如，戊酸可以预防炎症并保持肠道完整性. 人类体内低水平的戊酸与不同的疾病有关，比如儿童的神经性皮炎. 另外, 戊酸由于其作为组蛋白去乙酰化酶抑制剂(HDI)的特性而受到特别的研究。. hdi用于精神病学和神经病学，但越来越多的人对癌症治疗感兴趣, parasite infections and inflammatory diseases.
戊酸(其酯化形式)已被证明在家禽生产中发挥积极作用. The intestinal structure of broilers improves, 增加GLP-2的产生，被认为在促进肠道生长和增强肠道功能方面起着重要作用, resulting in better performance. 另一项研究报告了戊酸对减少产气荚膜梭菌攻击的影响(病变评分和死亡率)的有益作用, maintaining a good performance level when compared to esterified butyric acid.
Utilizing synergies to improve performance
In a trial performed in Spain (IMASDE) using 792 male broiler chickens (Ross 308 DOC, 每个处理12只重复笔，每个笔22只鸟)，以酯化形式将戊酸和丁酸混合的十大正规网堵平台(Gastrivix™Avi)与不使用任何饲料添加剂的对照组进行比较. Gastrivix™Avi significantly improved final body weight, 平均日增重(ADG)和饲料系数(货物收据)较对照组提高7.1%, 7.4% and 8 pts, respectively. Gastrivix™Avi在数值上提高了最终体重和平均日增重，在统计上提高了货物收据 3.8%, 3.9% and 6 pts compared to the tributyrins only group (表1). 与对照组和三丁酸甘油酯组相比，Gastrivix™Avi组在每个喂养阶段的数值和统计数据均有改善.
在本试验中，Gastrivix™Avi被证明是一种提高肉鸡生产性能的优良饲料添加剂. 另外, 数据表明，与单独使用丁酸酯相比，丁酸酯与戊酸酯(Gastrivix™Avi)组合在提高肉鸡生产性能方面表现出有益的效果.
| 参数 | 控制 | 三丁酸甘油酯(T) | 酪脂+ Valerins (BV) |
改进 BV vs C |
改进 BV vs T |
| 最终体重(克) | 2997 | 3022 | 3069 | + 2% | + 2% |
| ADG (g / d) | 72.0 | 72.7 | 73.8 | + 3% | + 2% |
| 货物收据 | 1.55b | 1.52a | 1.50a | - 5分 | - 2分 |
| EPEF | 458 | 453 | 469 | + 2% | + 4% |
表1. 2021年在西班牙(IMASDE)进行的肉鸡(Ross 308 DOC)试验的生产性能结果
在迄今为止使用该十大正规网堵平台的所有科学和半科学试验中，使用Gastrivix™Avi显示出在体重和货物收据方面的性能持续改善(如图1所示). 在8次试验中，货物收据的平均改善为4分，从而为十大正规网堵平台带来良好的投资回报，从而获得经济效益. As all producers are currently faced with increasing production prices, Gastrivix™Avi can be a tool to rely on to support gut integrity and performance.
图1. 饲粮中添加Gastrivix™Avi的肉仔鸡与不添加添加剂的对照组相比，饲料效率的提高. Perstorp在2019年至2021年期间与不同的合作伙伴合作进行了试验
References are available on request
